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Lucia Lombardi

Lombardi Research Lab

Pioneering BioNano Engineering for Peptide Therapeutics, Advanced Biomaterials and Bioinspired Solutions

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Articles in peer-reviewed journals

23.

Petrenas, Rokas, Hawkins, Olivia A., Jones, Jacob F., Scott, D. Arne, Fletcher, Jordan M., Obst, Ulrike, Lombardi, Lucia, Pirro, Fabio, Leggett, Graham J., Oliver, Thomas A. A., Woolfson, Derek N.

Confinement and Catalysis within De Novo Designed Peptide Barrels Journal Article

In: Journal of American Chemical Society, vol. 147, iss. 4, pp. 3796-3803, 2025.

Links

@article{,
title = {Confinement and Catalysis within \textit{De Novo} Designed Peptide Barrels},
author = {Rokas Petrenas and Olivia A. Hawkins and Jacob F. Jones and D. Arne Scott and Jordan M. Fletcher and Ulrike Obst and Lucia Lombardi and Fabio Pirro and Graham J. Leggett and Thomas A.A. Oliver and Derek N. Woolfson},
url = {https://doi.org/10.1021/jacs.4c16633},
year = {2025},
date = {2025-01-15},
urldate = {2025-01-15},
journal = {Journal of American Chemical Society},
volume = {147},
issue = {4},
pages = {3796-3803},
publisher = {American Chemical Society (ACS)},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

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  • https://doi.org/10.1021/jacs.4c16633

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Confinement and Catalysis within De Novo Designed Peptide Barrels
22.

Lombardi, Lucia, Granger, Luke A., Shattock, Robin J., Williams, Daryl R.

Advancements in Loop Cyclization Approaches for Enhanced Peptide Therapeutics for Targeting Protein–Protein Interactions Journal Article

In: The Journal of Organic Chemistry, vol. 90, iss. 4, pp. 1467-1477, 2024.

Links

@article{Lombardi_2024,
title = {Advancements in Loop Cyclization Approaches for Enhanced Peptide Therapeutics for Targeting Protein–Protein Interactions},
author = {Lucia Lombardi and Luke A. Granger and Robin J. Shattock and Daryl R. Williams},
url = {https://doi.org/10.1021/acs.joc.4c02178},
year = {2024},
date = {2024-11-01},
urldate = {2024-11-01},
journal = {The Journal of Organic Chemistry},
volume = {90},
issue = {4},
pages = {1467-1477},
publisher = {American Chemical Society (ACS)},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

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  • https://doi.org/10.1021/acs.joc.4c02178

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Advancements in Loop Cyclization Approaches for Enhanced Peptide Therapeutics for Targeting Protein–Protein Interactions
21.

Lombardi, Lucia, Li, Jiaxu, Williams, Daryl R.

Peptide-Based Biomaterials for Combatting Infections and Improving Drug Delivery Journal Article

In: Pharmaceutics, vol. 16, no. 11, pp. 1468, 2024.

Links

@article{Lombardi_2024b,
title = {Peptide-Based Biomaterials for Combatting Infections and Improving Drug Delivery},
author = {Lucia Lombardi and Jiaxu Li and Daryl R. Williams},
url = {http://dx.doi.org/10.3390/pharmaceutics16111468},
year = {2024},
date = {2024-11-01},
urldate = {2024-11-01},
journal = {Pharmaceutics},
volume = {16},
number = {11},
pages = {1468},
publisher = {MDPI AG},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

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  • http://dx.doi.org/10.3390/pharmaceutics16111468

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Peptide-Based Biomaterials for Combatting Infections and Improving Drug Delivery
20.

Dawson, William M., Shelley, Kathryn L., Fletcher, Jordan M., Scott, D. Arne, Lombardi, Lucia, Rhys, Guto G., LaGambina, Tania J., Obst, Ulrike, Burton, Antony J., Cross, Jessica A., Davies, George, Martin, Freddie J. O., Wiseman, Francis J., Brady, R. Leo, Tew, David, Wood, Christopher W., Woolfson, Derek N.

Differential sensing with arrays of de novo designed peptide assemblies Journal Article

In: Nature Communications, vol. 14, no. 1, 2023.

Links

@article{Dawson_2023,
title = {Differential sensing with arrays of de novo designed peptide assemblies},
author = {William M. Dawson and Kathryn L. Shelley and Jordan M. Fletcher and D. Arne Scott and Lucia Lombardi and Guto G. Rhys and Tania J. LaGambina and Ulrike Obst and Antony J. Burton and Jessica A. Cross and George Davies and Freddie J. O. Martin and Francis J. Wiseman and R. Leo Brady and David Tew and Christopher W. Wood and Derek N. Woolfson},
url = {http://dx.doi.org/10.1038/s41467-023-36024-y},
year = {2023},
date = {2023-01-01},
urldate = {2023-01-01},
journal = {Nature Communications},
volume = {14},
number = {1},
publisher = {Springer Science and Business Media LLC},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

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  • http://dx.doi.org/10.1038/s41467-023-36024-y

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Differential sensing with arrays of de novo designed peptide assemblies
19.

Musaimi, Othman Al, Lombardi, Lucia, Williams, Daryl R., Albericio, Fernando

Strategies for Improving Peptide Stability and Delivery Journal Article

In: Pharmaceuticals, vol. 15, no. 10, 2022.

Links

@article{AlMusaimi2022,
title = {Strategies for Improving Peptide Stability and Delivery},
author = {Othman Al Musaimi and Lucia Lombardi and Daryl R. Williams and Fernando Albericio},
url = {https://doi.org/10.3390/ph15101283},
year = {2022},
date = {2022-10-00},
urldate = {2022-10-00},
journal = {Pharmaceuticals},
volume = {15},
number = {10},
publisher = {MDPI AG},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

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  • https://doi.org/10.3390/ph15101283

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Strategies for Improving Peptide Stability and Delivery
18.

Musaimi, Othman Al, Morse, Sophie V., Lombardi, Lucia, Serban, Simona, Basso, Alessandra, Williams, Daryl R.

Successful synthesis of a glial‐specific blood–brain barrier shuttle peptide following a fragment condensation approach on a solid‐phase resin Journal Article

In: Journal of Peptide Science, vol. 29, no. 2, 2022.

Links

@article{Al_Musaimi_2022,
title = {Successful synthesis of a glial‐specific blood–brain barrier shuttle peptide following a fragment condensation approach on a solid‐phase resin},
author = {Othman Al Musaimi and Sophie V. Morse and Lucia Lombardi and Simona Serban and Alessandra Basso and Daryl R. Williams},
url = {http://dx.doi.org/10.1002/psc.3448},
year = {2022},
date = {2022-08-01},
urldate = {2022-08-01},
journal = {Journal of Peptide Science},
volume = {29},
number = {2},
publisher = {Wiley},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

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  • http://dx.doi.org/10.1002/psc.3448

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17.

Falanga, Annarita, Lombardi, Lucia, Galdiero, Emilia, Genio, Valentina Del, Galdiero, Stefania

The World of Cell Penetrating: the Future of Medical Applications Journal Article

In: Future Medicinal Chemistry, vol. 12, no. 15, pp. 1431–1446, 2020.

Links

@article{Falanga_2020,
title = {The World of Cell Penetrating: the Future of Medical Applications},
author = {Annarita Falanga and Lucia Lombardi and Emilia Galdiero and Valentina Del Genio and Stefania Galdiero},
url = {http://dx.doi.org/10.4155/fmc-2020-0140},
year = {2020},
date = {2020-07-01},
urldate = {2020-07-01},
journal = {Future Medicinal Chemistry},
volume = {12},
number = {15},
pages = {1431–1446},
publisher = {Informa UK Limited},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

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  • http://dx.doi.org/10.4155/fmc-2020-0140

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16.

Lombardi, L., Falanga, A., Genio, V. Del, Palomba, L., Galdiero, M., Franci, G., Galdiero, S.

A boost to the antiviral activity: Cholesterol tagged peptides derived from glycoprotein B of Herpes Simplex virus type I Journal Article

In: International Journal of Biological Macromolecules, vol. 162, pp. 882-893, 2020.

Links

@article{Lombardi2020,
title = {A boost to the antiviral activity: Cholesterol tagged peptides derived from glycoprotein B of Herpes Simplex virus type I},
author = {L. Lombardi and A. Falanga and V. Del Genio and L. Palomba and M. Galdiero and G. Franci and S. Galdiero},
url = {https://doi.org/10.1016/j.ijbiomac.2020.06.134},
year = {2020},
date = {2020-01-01},
urldate = {2020-01-01},
journal = {International Journal of Biological Macromolecules},
volume = {162},
pages = {882-893},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

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  • https://doi.org/10.1016/j.ijbiomac.2020.06.134

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15.

Galdiero, E., Siciliano, A., Lombardi, L., Falanga, A., Galdiero, S., Martucci, F., Guida, M.

Quantum dots functionalized with gH625 attenuate QDs oxidative stress and lethality in Caenorhabditis elegans: a model system Journal Article

In: Ecotoxicology, 2020.

Links

@article{Lombardi2020b,
title = {Quantum dots functionalized with gH625 attenuate QDs oxidative stress and lethality in Caenorhabditis elegans: a model system},
author = {E. Galdiero and A. Siciliano and L. Lombardi and A. Falanga and S. Galdiero and F. Martucci and M. Guida},
url = {https://doi.org/10.1007/s10646-019-02158-3},
year = {2020},
date = {2020-01-01},
urldate = {2020-01-01},
journal = {Ecotoxicology},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

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  • https://doi.org/10.1007/s10646-019-02158-3

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14.

Galdiero, Emilia, Alteriis, Elisabetta, Natale, Antonino De, D’Alterio, Angela, Siciliano, Antonietta, Guida, Marco, Lombardi, Lucia, Falanga, Annarita, Galdiero, Stefania

Eradication of Candida albicans persister cell biofilm by the membranotropic peptide gH625 Journal Article

In: Scientific Reports, vol. 10, no. 1, pp. 5780, 2020.

Links

@article{galdiero2020eradication,
title = {Eradication of Candida albicans persister cell biofilm by the membranotropic peptide gH625},
author = {Emilia Galdiero and Elisabetta Alteriis and Antonino De Natale and Angela D’Alterio and Antonietta Siciliano and Marco Guida and Lucia Lombardi and Annarita Falanga and Stefania Galdiero},
url = {https://doi.org/10.1038/s41598-020-62746-w},
year = {2020},
date = {2020-01-01},
urldate = {2020-01-01},
journal = {Scientific Reports},
volume = {10},
number = {1},
pages = {5780},
publisher = {Nature Publishing Group UK London},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

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  • https://doi.org/10.1038/s41598-020-62746-w

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13.

Galdiero, Emilia, Lombardi, Lucia, Falanga, Annarita, Libralato, Giovanni, Guida, Marco, Carotenuto, Rosa

Biofilms: Novel Strategies Based on Antimicrobial Peptides Journal Article

In: Pharmaceutics, vol. 11, no. 7, pp. 322, 2019.

Links

@article{Galdiero_2019,
title = {Biofilms: Novel Strategies Based on Antimicrobial Peptides},
author = {Emilia Galdiero and Lucia Lombardi and Annarita Falanga and Giovanni Libralato and Marco Guida and Rosa Carotenuto},
url = {https://doi.org/10.3390%2Fpharmaceutics11070322},
year = {2019},
date = {2019-07-01},
urldate = {2019-07-01},
journal = {Pharmaceutics},
volume = {11},
number = {7},
pages = {322},
publisher = {MDPI AG},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

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  • https://doi.org/10.3390%2Fpharmaceutics11070322

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12.

Lombardi, Lucia, Falanga, Annarita, Genio, Valentina Del, Galdiero, Stefania

A New Hope: Self-Assembling Peptides with Antimicrobial Activity Journal Article

In: Pharmaceutics, vol. 11, no. 4, pp. 166, 2019.

Links

@article{Lombardi_2019,
title = {A New Hope: Self-Assembling Peptides with Antimicrobial Activity},
author = {Lucia Lombardi and Annarita Falanga and Valentina Del Genio and Stefania Galdiero},
url = {http://dx.doi.org/10.3390/pharmaceutics11040166},
year = {2019},
date = {2019-04-01},
urldate = {2019-04-01},
journal = {Pharmaceutics},
volume = {11},
number = {4},
pages = {166},
publisher = {MDPI AG},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

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  • http://dx.doi.org/10.3390/pharmaceutics11040166

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11.

Pero, R., Angrisano, T., Brancaccio, M., Falanga, A., Lombardi, L., Natale, F., Laneri, S., Lombardo, B., Galdiero, S., Scudiero, O.

Beta-defensins and analogs in Helicobacter pylori infections: mRNA expression levels, DNA methylation, and antibacterial activity Journal Article

In: PLoS ONE, vol. 14, no. 9, 2019.

Links

@article{Lombardi2019,
title = {Beta-defensins and analogs in Helicobacter pylori infections: mRNA expression levels, DNA methylation, and antibacterial activity},
author = {R. Pero and T. Angrisano and M. Brancaccio and A. Falanga and L. Lombardi and F. Natale and S. Laneri and B. Lombardo and S. Galdiero and O. Scudiero},
url = {https://doi.org/10.1371/journal.pone.0222295},
year = {2019},
date = {2019-01-01},
urldate = {2019-01-01},
journal = {PLoS ONE},
volume = {14},
number = {9},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

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  • https://doi.org/10.1371/journal.pone.0222295

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10.

Lombardi, L., Shi, Y., Falanga, A., Galdiero, E., Alteriis, E. De, Franci, G., Chourpa, I., Azevedo, H. S., Galdiero, S.

Enhancing the Potency of Antimicrobial Peptides through Molecular Engineering and Self-Assembly Journal Article

In: Biomacromolecules, vol. 20, no. 3, pp. 1362-1374, 2019.

Links

@article{Lombardi2019b,
title = {Enhancing the Potency of Antimicrobial Peptides through Molecular Engineering and Self-Assembly},
author = {L. Lombardi and Y. Shi and A. Falanga and E. Galdiero and E. De Alteriis and G. Franci and I. Chourpa and H. S. Azevedo and S. Galdiero},
url = {https://doi.org/10.1021/acs.biomac.8b01740},
year = {2019},
date = {2019-01-01},
urldate = {2019-01-01},
journal = {Biomacromolecules},
volume = {20},
number = {3},
pages = {1362-1374},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

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  • https://doi.org/10.1021/acs.biomac.8b01740

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9.

Falanga, A., Iachetta, G., Lombardi, L., Perillo, E., Lombardi, A., Morelli, G., Valiante, S., Galdiero, S.

Enhanced uptake of gH625 by blood brain barrier compared to liver in vivo: characterization of the mechanism by an in vitro model and implications for delivery Journal Article

In: Scientific Reports, vol. 8, no. 1, 2018.

Links

@article{Lombardi2018,
title = {Enhanced uptake of gH625 by blood brain barrier compared to liver in vivo: characterization of the mechanism by an in vitro model and implications for delivery},
author = {A. Falanga and G. Iachetta and L. Lombardi and E. Perillo and A. Lombardi and G. Morelli and S. Valiante and S. Galdiero},
url = {https://doi.org/10.1038/s41598-018-32095-w},
year = {2018},
date = {2018-01-01},
urldate = {2018-01-01},
journal = {Scientific Reports},
volume = {8},
number = {1},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

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  • https://doi.org/10.1038/s41598-018-32095-w

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8.

Falanga, A., Mercurio, F. A., Siciliano, A., Lombardi, L., Galdiero, S., Guida, M., Libralato, G., Leone, M., Galdiero, E.

Metabolomic and oxidative effects of quantum dots-indolicidin on three generations of Daphnia magna Journal Article

In: Aquatic Toxicology, vol. 198, pp. 158-164, 2018.

Links

@article{Lombardi2018b,
title = {Metabolomic and oxidative effects of quantum dots-indolicidin on three generations of Daphnia magna},
author = {A. Falanga and F. A. Mercurio and A. Siciliano and L. Lombardi and S. Galdiero and M. Guida and G. Libralato and M. Leone and E. Galdiero},
url = {https://doi.org/10.1016/j.aquatox.2018.03.001},
year = {2018},
date = {2018-01-01},
urldate = {2018-01-01},
journal = {Aquatic Toxicology},
volume = {198},
pages = {158-164},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

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  • https://doi.org/10.1016/j.aquatox.2018.03.001

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7.

Alteriis, E., Lombardi, L., Falanga, A., Napolano, M., Galdiero, S., Siciliano, A., Carotenuto, R., Guida, M., Galdiero, E.

Polymicrobial antibiofilm activity of the membranotropic peptide gH625 and its analogue Journal Article

In: Microbial Pathogenesis, vol. 125, pp. 189-195, 2018.

Links

@article{Lombardi2018c,
title = {Polymicrobial antibiofilm activity of the membranotropic peptide gH625 and its analogue},
author = {E. Alteriis and L. Lombardi and A. Falanga and M. Napolano and S. Galdiero and A. Siciliano and R. Carotenuto and M. Guida and E. Galdiero},
url = {https://doi.org/10.1016/j.micpath.2018.09.027},
year = {2018},
date = {2018-01-01},
urldate = {2018-01-01},
journal = {Microbial Pathogenesis},
volume = {125},
pages = {189-195},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

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  • https://doi.org/10.1016/j.micpath.2018.09.027

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6.

Lombardi, L., Stellato, M. I., Oliva, R., Falanga, A., Galdiero, M., Petraccone, L., D'Errico, G., Santis, A. De, Galdiero, S., Vecchio, P. Del

Antimicrobial peptides at work: Interaction of myxinidin and its mutant WMR with lipid bilayers mimicking the P. aeruginosa and E. coli membranes Journal Article

In: Scientific Reports, vol. 7, 2017.

Links

@article{Lombardi2017,
title = {Antimicrobial peptides at work: Interaction of myxinidin and its mutant WMR with lipid bilayers mimicking the P. aeruginosa and E. coli membranes},
author = {L. Lombardi and M. I. Stellato and R. Oliva and A. Falanga and M. Galdiero and L. Petraccone and G. D'Errico and A. De Santis and S. Galdiero and P. Del Vecchio},
url = {https://doi.org/10.1038/srep44425},
year = {2017},
date = {2017-01-01},
urldate = {2017-01-01},
journal = {Scientific Reports},
volume = {7},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

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  • https://doi.org/10.1038/srep44425

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5.

Galdiero, E., Falanga, A., Siciliano, A., Maselli, V., Guida, M., Carotenuto, R., Tussellino, M., Lombardi, L., Benvenuto, G., Galdiero, S.

Daphnia magna and Xenopus laevis as in vivo models to probe toxicity and uptake of quantum dots functionalized with gH625 Journal Article

In: International Journal of Nanomedicine, vol. 12, pp. 2717-2731, 2017.

Links

@article{Lombardi2017b,
title = {Daphnia magna and Xenopus laevis as in vivo models to probe toxicity and uptake of quantum dots functionalized with gH625},
author = {E. Galdiero and A. Falanga and A. Siciliano and V. Maselli and M. Guida and R. Carotenuto and M. Tussellino and L. Lombardi and G. Benvenuto and S. Galdiero},
url = {https://doi.org/10.2147/IJN.S127226},
year = {2017},
date = {2017-01-01},
urldate = {2017-01-01},
journal = {International Journal of Nanomedicine},
volume = {12},
pages = {2717-2731},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

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  • https://doi.org/10.2147/IJN.S127226

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4.

Falanga, A., Lombardi, L., Tarallo, R., Franci, G., Perillo, E., Palomba, L., Galdiero, M., Pontoni, D., Fragneto, G., Weck, M., Galdiero, S.

The intriguing journey of gH625-dendrimers Journal Article

In: RSC Advances, vol. 7, no. 15, pp. 9106-9114, 2017.

Links

@article{Lombardi2017c,
title = {The intriguing journey of gH625-dendrimers},
author = {A. Falanga and L. Lombardi and R. Tarallo and G. Franci and E. Perillo and L. Palomba and M. Galdiero and D. Pontoni and G. Fragneto and M. Weck and S. Galdiero},
url = {https://doi.org/10.1039/C6RA28405A},
year = {2017},
date = {2017-01-01},
urldate = {2017-01-01},
journal = {RSC Advances},
volume = {7},
number = {15},
pages = {9106-9114},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

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  • https://doi.org/10.1039/C6RA28405A

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3.

Galdiero, E., Siciliano, A., Maselli, V., Gesuele, R., Guida, M., Fulgione, D., Galdiero, S., Lombardi, L., Falanga, A.

An integrated study on antimicrobial activity and ecotoxicity of quantum dots and quantum dots coated with the antimicrobial peptide indolicidin Journal Article

In: International Journal of Nanomedicine, vol. 11, pp. 4199-4211, 2016.

Links

@article{Lombardi2016,
title = {An integrated study on antimicrobial activity and ecotoxicity of quantum dots and quantum dots coated with the antimicrobial peptide indolicidin},
author = {E. Galdiero and A. Siciliano and V. Maselli and R. Gesuele and M. Guida and D. Fulgione and S. Galdiero and L. Lombardi and A. Falanga},
url = {https://doi.org/10.2147/IJN.S107752},
year = {2016},
date = {2016-01-01},
urldate = {2016-01-01},
journal = {International Journal of Nanomedicine},
volume = {11},
pages = {4199-4211},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

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  • https://doi.org/10.2147/IJN.S107752

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2.

Falanga, A., Lombardi, L., Franci, G., Vitiello, M., Iovene, M. R., Morelli, G., Galdiero, M., Galdiero, S.

Marine antimicrobial peptides: Nature provides templates for the design of novel compounds against pathogenic bacteria Journal Article

In: International Journal of Molecular Sciences, vol. 17, no. 5, 2016.

Links

@article{Lombardi2016b,
title = {Marine antimicrobial peptides: Nature provides templates for the design of novel compounds against pathogenic bacteria},
author = {A. Falanga and L. Lombardi and G. Franci and M. Vitiello and M. R. Iovene and G. Morelli and M. Galdiero and S. Galdiero},
url = {https://doi.org/10.3390/ijms17050785},
year = {2016},
date = {2016-01-01},
urldate = {2016-01-01},
journal = {International Journal of Molecular Sciences},
volume = {17},
number = {5},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

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  • https://doi.org/10.3390/ijms17050785

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1.

Gerelli, Y., Porcar, L., Lombardi, L., Fragneto, G.

Lipid exchange and flip-flop in solid supported bilayers Journal Article

In: Langmuir, vol. 29, no. 41, pp. 12762-12769, 2013.

Links

@article{Lombardi2013,
title = {Lipid exchange and flip-flop in solid supported bilayers},
author = {Y. Gerelli and L. Porcar and L. Lombardi and G. Fragneto},
url = {https://dx.doi.org/10.1021/la402708u},
year = {2013},
date = {2013-01-01},
urldate = {2013-01-01},
journal = {Langmuir},
volume = {29},
number = {41},
pages = {12762-12769},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

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  • https://dx.doi.org/10.1021/la402708u

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Office and Lab

School of Biological Sciences
Queen's University Belfast
19 Chlorine Gardens
Belfast, BT9 5DL
United Kingdom

Other affiliation

Department of Chemical Engineering
Imperial College London
South Kensington Campus
London, SW7 2AZ
United Kingdom

Contacts

l.lombardi@qub.ac.uk

Lombardi Research Lab.

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